HCC: A Deadly Tumour on the Rise
- Liver cancer is the sixth most frequent form of cancer worldwide and is the third leading cause of cancer-related mortality2
- Most cases of HCC arise as a result of chronic liver inflammation or injury3
- The incidence of HCC is increasing due to the long-term consequences of chronic hepatitis C and hepatitis B viral infections4
- Most patients newly diagnosed with HCC are not candidates for curative treatment because of invasive or metastatic disease and/or poor liver function5
Liver injury and HCC
It is believed that most cases of HCC arise as a result of chronic liver injury3
- Chronic injury increases hepatocyte turnover in an environment of inflammation and oxidative DNA damage
- Mitogenic and mutagenic conditions promote random mutations that may lead to cell transformation and development of HCC
Nexavar Chart - Factors involved in the phatogenesis of hepatocellular carcinoma
Adapted with permission from Moradpour and Blum.3
Diagnosis of liver cancer among other focal liver lesions
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Next: HCC Risk Factors
Term
Explanation for term.
