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Cirrhosis Is a Key Concern

• The single greatest risk factor for development of HCC is cirrhosis, which is present in 80% to 90% of patients who develop HCC⁶
• The risk factors that lead to the development of HCC vary by geographic region⁷
  • Up to 70% of patients in Europe or North America present with cirrhosis from hepatitis C infection
    
  • 70% of patients in Asia or Africa (excluding Japan) present with cirrhosis from hepatitis B infection
    
  • 70% of patients in Japan present with cirrhosis from hepatitis C infection
  • 10% of those patients present with cirrhosis from alcohol use in the absence of hepatitis C or hepatitis B infection globally
  • <10% of those patients present with cirrhosis from other causes* globally

  *Which includes haemochromatosis and aflatoxin B₁ intake from contaminated food.

Nexavar Chart - Risk factors associated with the development of HCC worldwide, by geographic region (2000)

^aExcluding Japan

Underlying conditions associated with the development of HCC^3,6,8

Nexavar Chart - Underlying conditions associated with the development of HCC

Next: Pivotal Study: The SHARP Trial

 

Term

Explanation for term.