The RAS/RAF/MEK/ERK Pathway and HCC
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Mitogen-Activated Protein Kinase (MAPK) Signalling Plays a Key Role in Governing Cell Proliferation, Differentiation, and Survival2

MAPK signalling is transmitted along the RAS/RAF/MEK/ERK pathway as follows:

  • Activation of the small Gprotein RAS recruits of RAF1 to the inner surface of the cell membrane3
  • RAF1 phosphorylates MEK3
  • MEK phosphorylates and activates ERK downstream3
  • Activated ERK translocates to the cell nucleus and regulates gene expression by interacting with various transcription factors4

ERK expression can be associated with more aggressive HCC

ERK expression in HCC is associated with5

  • Increased tumour size
  • Histologic progression
  • Intrahepatic metastasis

Next: Uncontrolled Activation of the RAF/MAP/ERK Pathway
 
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