Nexavar Mechanism of Action
- + Text Zoom

Nexavar — A Unique Multikinase Inhibitor

Nexavar works along multiple signalling pathways to block cell proliferation and tumour angiogenesis.*

Nexavar is the only multikinase inhibitor that blocks the receptor tyrosine kinases VEGFR (Vascular Endothelial Growth Factor Receptor) and PDGFR (Platelet Derived Growth Factor Receptor) and the RAF serine/threonine kinases along the RAF/MEK/ERK pathway




Nexavar Chart – Sorafenib targets both tumor-cell proliferation and angiogenesis in vitro

Adapted from Wilhelm et al 20041


*In preclinical models


Next: The RAS/RAF/MEK/ERK Pathway and HCC
 
Term
Explanation for term.