The Biology of Advanced RCC Provides a Strong Rationale for Targeted Therapy

• Due to the inactivation of the von Hippel-Lindau (VHL) tumour-suppressor gene, vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) are overexpressed in advanced RCC⁷
• The receptors VEGF and PDGF play important roles in tumour angiogenesis⁷
• Serine/threonine kinases within the RAF/MEK/ERK pathway play roles in both tumour angiogenesis and tumour cell proliferation in advanced RCC⁸

Multiple levels of multikinase activation increase tumour cell proliferation and tumour angiogenesis^7,8

Multiple levels of multikinase activation increase tumour cell proliferation and tumour angiogenesis